Keywords
high altitude; hypoxia; respiratory adaptation; hypoxic ventilatory response; acclimatization; erythropoietin; carotid body; pulmonary physiology; HIF-1alpha; altitude sickness
How to Cite
ADAPTIVE CHANGES IN RESPIRATORY PARAMETERS UNDER HIGH-ALTITUDE HYPOXIA: A SYSTEMATIC REVIEW. (2026). Global Conference on Medical and Health Sciences, 1(4), 615-623. http://www.econferencia.com/index.php/5/article/view/639
Abstract
Background: Exposure to high-altitude environments (>2500 m above sea level) subjects the human body to progressive hypobaric hypoxia, triggering a complex series of physiological adaptations primarily orchestrated through the respiratory system. These adaptive responses — spanning ventilatory, hematological, and cellular levels — determine individual tolerance to altitude and underlie the pathophysiology of altitude-related illnesses. Objective: This study aimed to systematically review and analyze the adaptive changes in respiratory parameters occurring under high-altitude hypoxic conditions, with emphasis on the temporal sequence of acclimatization and the physiological mechanisms involved. Methods: A systematic review of 10 peer-reviewed studies published between 2012 and 2024 was conducted, encompassing human field studies, controlled hypobaric chamber experiments, and comparative investigations of lowlander versus high-altitude native populations.
References
This work is licensed under a Creative Commons Attribution 4.0 International License.
Most read articles by the same author(s)
- Arziqulov Fazliddin, Amirqulov Raxmatulla, Amirqulova Sugdiyona, ARSMEDICA: AN ARTIFICIAL INTELLIGENCE–DRIVEN PLATFORM FOR SCHOLARLY DATABASE NAVIGATION AND SCIENTIFIC PUBLISHING SUPPORT , Global Conference on Medical and Health Sciences: Vol. 1 No. 3 (2026): GCMHS
- Amirqulov Raxmatulla, Amirqulova Sug‘diyona, Xayrullayev Islomjon, SYMPATHETIC NERVOUS SYSTEM ACTIVATION UNDER CHRONIC STRESS AND ITS SYSTEMIC EFFECTS ON THE HUMAN BODY , Global Conference on Medical and Health Sciences: Vol. 1 No. 4 (2026): GCMHS
- Amirqulov Raxmatulla, Amirqulova Sug‘diyona, Xayrullayev Islomjon, PERSONALIZED MEDICINE IN NEUROLOGY: INTEGRATING GENOMICS, ARTIFICIAL INTELLIGENCE, AND MULTIMODAL CLINICAL DATA FOR PRECISION DIAGNOSIS AND TREATMENT , Global Conference on Medical and Health Sciences: Vol. 1 No. 4 (2026): GCMHS
- Amirqulov Raxmatulla, Amirqulova Sug‘Diyona, Xayrullayev Islomjon, HYBRID NEUROTECHNOLOGIES: INTEGRATING NANOTECHNOLOGY AND NEUROSCIENCE FOR PRECISION TARGETED BRAIN THERAPY AND ADVANCED NEUROTHERAPEUTIC INNOVATION , Global Conference on Medical and Health Sciences: Vol. 1 No. 4 (2026): GCMHS
- Amirqulov Raxmatulla, Amirqulova Sug‘diyona, Xayrullayev Islomjon, BRAIN–COMPUTER INTERFACES IN NEUROLOGICAL REHABILITATION: TECHNOLOGICAL INNOVATIONS, NEURAL DECODING STRATEGIES, AND CLINICAL TRANSLATION CHALLENGES IN MODERN NEUROREHABILITATION , Global Conference on Medical and Health Sciences: Vol. 1 No. 4 (2026): GCMHS
- Amirqulov Raxmatulla, Amirqulova Sug‘diyona, Xayrullayev Islomjon, NEUROETHICS IN THE ERA OF ARTIFICIAL INTELLIGENCE AND BRAIN TECHNOLOGIES: ETHICAL, LEGAL, AND SOCIETAL IMPLICATIONS OF EMERGING NEUROTECHNOLOGIES , Global Conference on Medical and Health Sciences: Vol. 1 No. 4 (2026): GCMHS
- Amirqulov Raxmatulla, Amirqulova Sug‘diyona, AUTONOMIC NERVOUS SYSTEM DYSREGULATION IN NEUROLOGICAL DISORDERS: BEYOND HRV , Global Conference on Medical and Health Sciences: Vol. 1 No. 6 (2026): GCMHS
- Amirqulov Raxmatulla, Amirqulova Sug‘diyona, BIOMECHANICAL MODELING OF BRAIN TISSUE FOR SAFER NEUROSURGICAL INTERVENTIONS: COMPUTATIONAL STRATEGIES FOR PRECISION PLANNING, DEFORMATION PREDICTION, AND INTRAOPERATIVE RISK REDUCTION , Global Conference on Medical and Health Sciences: Vol. 1 No. 6 (2026): GCMHS
- Amirqulov Raxmatulla, Amirqulova Sug‘diyona, LONG-TERM NEUROLOGICAL CONSEQUENCES OF ENVIRONMENTAL AND LIFESTYLE FACTORS: MECHANISMS, RISK MODIFIERS, AND PREVENTIVE STRATEGIES IN BRAIN HEALTH , Global Conference on Medical and Health Sciences: Vol. 1 No. 4 (2026): GCMHS
- Amirqulov Raxmatulla, Amirqulova Sug‘diyona, Xayrullayev Islomjon, EFFECTS OF SLEEP DISORDERS ON BRAIN NEUROTRANSMITTER BALANCE: A SYSTEMATIC REVIEW , Global Conference on Medical and Health Sciences: Vol. 1 No. 4 (2026): GCMHS
Similar Articles
- Satima R. Kuranbayeva, Fazliddin Arzikulov, NEUROIMAGING AI FOR TMS TARGET LOCALISATION: EVIDENCE FOR INDIVIDUALISED COIL PLACEMENT IN DEPRESSION AND NEUROREHABILITATION , Global Conference on Medical and Health Sciences: Vol. 1 No. 6 (2026): GCMHS
- Fazliddin Arzikulov, Iroda Khadjimatova, MACHINE LEARNING FOR PERSONALIZED DRUG DOSING IN CHILDREN: PHARMACOKINETIC MODELING AND CLINICAL VALIDATION , Global Conference on Medical and Health Sciences: Vol. 1 No. 6 (2026): GCMHS
- Khoshimov I. G., Yakubov N. I.,, Madumarova Z. Sh, Zulunov A. T., TUMOR-RELATED CEREBRAL EDEMA: MECHANISMS AND IMAGING FEATURES , Global Conference on Medical and Health Sciences: Vol. 1 No. 2 (2026): GCMHS
- Fazliddin Arzikulov, Azizbek Sattarov, Rakhmatilla Amirkulov, WEARABLE HEALTH TECHNOLOGIES AND REMOTE PATIENT MONITORING: CLINICAL EVIDENCE, IMPLEMENTATION CHALLENGES, AND FUTURE DIRECTIONS , Global Conference on Medical and Health Sciences: Vol. 1 No. 6 (2026): GCMHS
- Tuxtaev Vakhobjon Husenovich, FINANCIAL STRATEGIES AND INVESTMENT PROJECT EVALUATION MECHANISMS FOR SUSTAINABLE TRANSPORT-LOGISTICS INFRASTRUCTURE , Global Conference on Medical and Health Sciences: Vol. 1 No. 1 (2026): GCMHS
- Mardanov Vohid Narzullaevich, LAPAROSCOPIC ADHESIOLYSIS WITH ANTIADHESION BARRIERS VERSUS TRADITIONAL LAPAROTOMY IN ACUTE ADHESIVE SMALL BOWEL OBSTRUCTION: CLINICAL OUTCOMES , Global Conference on Medical and Health Sciences: Vol. 1 No. 6 (2026): GCMHS
- Amirqulov Rahmatilla, Arziqulov Fazliddin, Xayrullayev Islomjon, DEEP LEARNING-BASED PREDICTION OF POSTOPERATIVE NEUROLOGICAL DEFICITS IN BRAIN TUMOR SURGERY: ENHANCING RISK STRATIFICATION AND CLINICAL DECISION-MAKING , Global Conference on Medical and Health Sciences: Vol. 1 No. 4 (2026): GCMHS
- Madona Kebadze, Lia Baindurashvili, Nino Chankotadze, DIGITAL TRANSFORMATION IN HIGHER EDUCATION: STUDENT ENGAGEMENT AND THE EFFECTIVENESS OF DIGITAL LEARNING RESOURCES , Global Conference on Medical and Health Sciences: Vol. 1 No. 3 (2026): GCMHS
- Satima R. Kuranbayeva, Fazliddin Arzikulov, PREDICTING POST-STROKE COGNITIVE IMPAIRMENT WITH MACHINE LEARNING: A REVIEW OF NEUROIMAGING, CLINICAL, AND BLOOD BIOMARKER APPROACHES , Global Conference on Medical and Health Sciences: Vol. 1 No. 6 (2026): GCMHS
- Po‘latov Ma’rufjon Davlatbek o‘g‘li, EARLY DIAGNOSIS AND PROGNOSTIC OPTIMIZATION OF ACUTE KIDNEY INJURY IN THE INTENSIVE CARE SETTING , Global Conference on Medical and Health Sciences: Vol. 1 No. 2 (2026): GCMHS
You may also start an advanced similarity search for this article.